CD71 (Transferrin Receptor)
نویسندگان
چکیده
منابع مشابه
Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia.
Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake. Higher expression of CD71 has been identified as a negative prognostic marker for numerous solid tumor types and for some lymphomas. The aim of this study was to evaluate CD71 expression on acute lymphoblastic leukemia (ALL) cells and to follow its possible clinical correlations. Sixty one patien...
متن کاملOverexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal cancer in endemic Asian regions. In the present study, we investigated the clinical implication and role of transferrin receptor CD71 in ESCC. CD71 has a physiological role in cellular iron intake and is implicated in the carcinogenesis of various types of tumors. In our cohort, more than a 2-fold upregulation of th...
متن کاملHeterotypic interactions between transferrin receptor and transferrin receptor 2.
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism. TfR2 is capable of Tf-mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis...
متن کاملHeterotypic interactions between Transferrin Receptor and Transferrin
http://bloodjournal.hematologylibrary.org/content/101/5/2008.full.html Updated information and services can be found at: (1174 articles) Red Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in...
متن کاملDiferric transferrin regulates transferrin receptor 2 protein stability.
Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf). Mutations in TfR2 cause one form of hereditary hemochromatosis, a disease in which excessive absorption of dietary iron can lead to liver cirrhosis, diabetes, arthritis, and heart failure. The function of TfR2 in iron homeostasis is unknown. We have studied the regula...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2010
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcpcrk3moaoj6at